Old friends in new guise: repositioning of known drugs with structural bioinformatics
نویسندگان
چکیده
Developing a drug de novo is a laborious and costly endeavor. Thus, the repositioning of already approved drugs for the treatment of new diseases is promising and valuable. One computational approach to repositioning exploits the structural similarity of binding sites of known and new targets. Here, we review computational methods to represent and align binding sites. We review available tools, present success stories and discuss limits of the approach.
منابع مشابه
Drug repositioning based on comprehensive similarity measures and Bi-Random walk algorithm
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عنوان ژورنال:
- Briefings in bioinformatics
دوره 12 4 شماره
صفحات -
تاریخ انتشار 2011